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Scientists identify key mechanism controlling skin regeneration Date: August 3, 2022 Source: Northwestern University Summary: The outer layer of skin, the epidermis, is constantly turning over to replace dead or damaged cells throughout our lifetime. Skin stem cells need to continuously make decisions: either make more copies of themselves (self-renewal) or switch their fate towards differentiation. The molecular mechanisms controlling this process remain poorly understood. Now a research team has identified a molecular switch that plays an early and critical role in the skin stem cell differentiation process. Story Source: Materials provided by Northwestern University. Original written by Megan Fellman. Note: Content may be edited for style and length. Journal Reference: Sarah M. Lloyd, Daniel B. Leon, Mari O. Brady, Deborah Rodriguez, Madison P. McReynolds, Junghun Kweon, Amy E. Neely, Laura A. Blumensaadt, Patric J. Ho, Xiaomin Bao. CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-32098-2

Hyaluranic acid, a naturally occurring compound, awakens stem cells to repair damaged muscle Date: August 4, 2022 Source: The Ottawa Hospital Summary: A new study reveals a unique form of cell communication that controls muscle repair.